Article
No Association Between CEL-HYB Hybrid Allele and Chronic Pancreatitis in Asian Populations.
Gastroenterology - 1 Jun 2016
Zou Wen-Bin, Boulling Arnaud, Masamune Atsushi, Issarapu Prachand, Masson Emmanuelle, Wu Hao, Sun Xiao-Tian, Hu Liang-Hao, Zhou Dai-Zhan, He Lin, Fichou Yann, Nakano Eriko, Hamada Shin, Kakuta Yoichi, Kume Kiyoshi, Isayama Hiroyuki, Paliwal Sumit, Mani K Radha, Bhaskar Seema, Cooper David N, Férec Claude, Shimosegawa Tooru, Chandak Giriraj R, Chen Jian-Min, Li Zhao-Shen, Liao Zhuan
Abstract excerpt
A hybrid allele between the carboxyl ester lipase gene (CEL) and its pseudogene, CELP (called CEL-HYB), generated by nonallelic homologous recombination between CEL intron 10 and CELP intron 10', was found to increase susceptibility to chronic pancreatitis in a case-control study of patients of European ancestry. We attempted to replicate this finding in 3 independent cohorts from China, Japan, and India, but...
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