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Article

Demographically-Based Evaluation of Genomic Regions under Selection in Domestic Dogs.

PLoS genetics - 1 Mar 2016

Freedman Adam H, Schweizer Rena M, Ortega-Del Vecchyo Diego, Han Eunjung, Davis Brian W, Gronau Ilan, Silva Pedro M, Galaverni Marco, Fan Zhenxin, Marx Peter, Lorente-Galdos Belen, Ramirez Oscar, Hormozdiari Farhad, Alkan Can, Vilà Carles, Squire Kevin, Geffen Eli, Kusak Josip, Boyko Adam R, Parker Heidi G, Lee Clarence, Tadigotla Vasisht, Siepel Adam, Bustamante Carlos D, Harkins Timothy T, Nelson Stanley F, Marques-Bonet Tomas, Ostrander Elaine A, Wayne Robert K, Novembre John

Abstract excerpt

Controlling for background demographic effects is important for accurately identifying loci that have recently undergone positive selection. To date, the effects of demography have not yet been explicitly considered when identifying loci under selection during dog domestication. To investigate positive selection on the dog lineage early in the domestication, we examined patterns of polymorphism in six canid...

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Source

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Identifiers

PMID: 26943675
DOI: 10.1371/journal.pgen.1005851
PMCID: PMC4778760

Genes

CADM2
GLRA1
GRIK3
LHFPL3
MBP
NTAN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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