Article
PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast.
The Journal of biological chemistry - 29 Apr 2016
Grewal Jaspreet S, McLuskey Karen, Das Debanu, Myburgh Elmarie, Wilkes Jonathan, Brown Elaine, Lemgruber Leandro, Gould Matthew K, Burchmore Richard J, Coombs Graham H, Schnaufer Achim, Mottram Jeremy C
Abstract excerpt
The structure of a C11 peptidase PmC11 from the gut bacterium, Parabacteroides merdae, has recently been determined, enabling the identification and characterization of a C11 orthologue, PNT1, in the parasitic protozoon Trypanosoma brucei. A phylogenetic analysis identified PmC11 orthologues in bacteria, archaea, Chromerids, Coccidia, and Kinetoplastida, the latter being the most divergent. A primary sequence...
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