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Article

Interleukin-1β Promoter Polymorphism Enhances the Risk of Sleep Disturbance in Alzheimer's Disease.

PloS one - 1 Jan 2016

Yin You, Liu Yan, Pan Xiao, Chen Rui, Li Peng, Wu Hui-Juan, Zhao Zheng-Qing, Li Yan-Peng, Huang Liu-Qing, Zhuang Jian-Hua, Zhao Zhong-Xin

Abstract excerpt

Sleep alleviates Alzheimer's disease (AD)-related neuropathological processes, whereas sleep disturbance in AD patients is associated with elevated peripheral inflammatory cytokine levels. In the present study, we assessed interleukin (IL)-1β and APOEε4 polymorphisms for association with susceptibility of sleep disturbances in AD patients. A total of 123 pretreated AD patients and 120 age-, gender- and education...

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Identifiers

PMID: 26937653
DOI: 10.1371/journal.pone.0149945
PMCID: PMC4777499

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TNF

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