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Article

Ezrin Enhances EGFR Signaling and Modulates Erlotinib Sensitivity in Non-Small Cell Lung Cancer Cells.

Neoplasia (New York, N.Y.) - 1 Feb 2016

Saygideğer-Kont Yasemin, Minas Tsion Zewdu, Jones Hayden, Hour Sarah, Çelik Haydar, Temel Idil, Han Jenny, Atabey Nese, Erkizan Hayriye Verda, Toretsky Jeffrey A, Üren Aykut

Abstract excerpt

Ezrin is a scaffolding protein that is involved in oncogenesis by linking cytoskeletal and membrane proteins. Ezrin interacts with epidermal growth factor receptor (EGFR) in the cell membrane, but little is known about the effects of this interaction on EGFR signaling pathway. In this study, we established the biological and functional significance of ezrin-EGFR interaction in non-small cell lung cancer (NSCLC)...

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Share to Carcinoma, Non-Small-Cell Lung
Share to Cytoskeletal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to ErbB Receptors

Share to Erlotinib Hydrochloride

Share to Neoplasm Proteins

Share to Protein Kinase Inhibitors

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Source

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Identifiers

PMID: 26936397
DOI: 10.1016/j.neo.2016.01.002
PMCID: PMC5005263

Genes

EGFR
AURKA
EGF
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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