Article
Using the Collaborative Cross to Study the Role of Genetic Diversity in Cancer-Related Phenotypes.
Cold Spring Harbor protocols - 1 Mar 2016
Reilly Karlyne M
Abstract excerpt
Human populations are genetically diverse and often a single mouse model can only represent a small subset of the human population. Studying genetic diversity directly can improve the predictive value of mouse models of cancer biology and research on the effects of carcinogens and therapeutics in humans. The collaborative cross is a panel of inbred mouse lines that captures 90% of the genetic diversity of the Mus...
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