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Inhibition of FoxM1 -Mediated DNA Repair by Imipramine Blue Suppresses Breast Cancer Growth and Metastasis

29 Feb 2016

Abstract excerpt

PURPOSE: The approaches aimed at inhibiting the ability of cancer cells to repair DNA strand breaks have emerged as promising targets for treating cancers. Here, we assessed the potential of imipramine blue (IB), a novel analogue of antidepressant imipramine, to suppress breast cancer growth and metastasis by inhibiting the ability of breast cancer cells to repair DNA strand breaks by homologous recombination...

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PMID: 26927663
DOI: 10.1158/1078-0432.ccr-15-2535

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