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Cytochrome P450 1B1 mRNA untranslated regions interact to inhibit protein translation

11 Nov 2009

Abstract excerpt

CYP1B1 mRNA is expressed constitutively in all normal extrahepatic human tissues, though the protein is usually undetectable. In contrast, CYP1B1 protein is expressed at high levels in tumors. In this study CYP1B1 mRNA and protein expression was measured in a panel of cell lines indicating that CYP1B1 regulation is altered in tumor cell lines in vitro. Interrogation of ONCOMINE revealed that CYP1B1 mRNA is not...

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PMID: 19908239
DOI: 10.1002/mc.20589

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