Article
Validation of the FAM19A4/mir124-2 DNA methylation test for both lavage- and brush-based self-samples to detect cervical (pre)cancer in HPV-positive women.
Gynecologic oncology - 1 May 2016
De Strooper Lise M A, Verhoef Viola M J, Berkhof Johannes, Hesselink Albertus T, de Bruin Helena M E, van Kemenade Folkert J, Bosgraaf Remko P, Bekkers Ruud L M, Massuger Leon F A G, Melchers Willem J G, Steenbergen Renske D M, Snijders Peter J F, Meijer Chris J L M, Heideman Daniëlle A M
Abstract excerpt
OBJECTIVES: DNA methylation analysis of cancer-related genes is a promising tool for HPV-positive women to identify those with cervical (pre)cancer (CIN3+) in need of treatment. However, clinical performance of methylation markers can be influenced by the sample type utilized. We describe a multiplex quantitative methylation-specific PCR that targets FAM19A4 and mir124-2 loci, to detect CIN3+ using both...
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