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Article

Improvement in detection of minor alleles in next generation sequencing by base quality recalibration.

BMC genomics - 27 Feb 2016

Ni Shengyu, Stoneking Mark

Abstract excerpt

BACKGROUND: Minor allele detection in very high coverage sequence data (>1000X) has many applications such as detecting mtDNA heteroplasmy, somatic mutations in cancer or tumors, SNP calling in pool sequencing, etc., where reads with low frequency are not necessarily sequence error but may instead convey biological information. However, the suitability of common base quality recalibration tools for such...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26920804
DOI: 10.1186/s12864-016-2463-2
PMCID: PMC4769523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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