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Article

Small cell lung cancer: Circulating tumor cells of extended stage patients express a mesenchymal-epithelial transition phenotype.

Cell adhesion & migration - 3 Jul 2016

Hamilton Gerhard, Hochmair Maximilian, Rath Barbara, Klameth Lukas, Zeillinger Robert

Abstract excerpt

Small cell lung cancer (SCLC) is distinguished by aggressive growth, early dissemination and a poor prognosis at advanced stage. The remarkably high count of circulating tumor cells (CTCs) of SCLC allowed for the establishment of permanent CTC cultures at our institution for the first time. CTCs are assumed to have characteristics of cancer stem cells (CSCs) and an epithelial-mesenchymal transition (EMT)...

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Source

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Identifiers

PMID: 26919626
DOI: 10.1080/19336918.2016.1155019
PMCID: PMC4986707

Genes

FOXA2
KDR
MET
SOX17
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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