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Article

miR-342 overexpression results in a synthetic lethal phenotype in BRCA1-mutant HCC1937 breast cancer cells.

Oncotarget - 5 Apr 2016

Crippa Elisabetta, Folini Marco, Pennati Marzia, Zaffaroni Nadia, Pierotti Marco A, Gariboldi Manuela

Abstract excerpt

Expression of miR-342 has been strongly correlated with estrogen receptor (ER) status in breast cancer, where it is highest in ER-positive and lowest in triple-negative tumors. We investigated the effects of miR-342 transfection in the triple-negative breast cancer cell lines MDA-MB-231 and HCC1937, the latter carrying a germ-line BRCA1 mutation. Reconstitution of miR-342 led to caspase-dependent induction of...

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Share to Apoptosis
Share to BRCA1 Protein
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Triple Negative Breast Neoplasms

Source

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Identifiers

PMID: 26919240
DOI: 10.18632/oncotarget.7617
PMCID: PMC4951312

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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