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Article

AKT-independent protection of prostate cancer cells from apoptosis mediated through complex formation between the androgen receptor and FKHR.

Molecular and cellular biology - 1 Jan 2003

Li Pengfei, Lee Heehyoung, Guo Shaodong, Unterman Terry G, Jenster Guido, Bai Wenlong

Abstract excerpt

Recent studies suggested that the protection of cell apoptosis by AKT involves phosphorylation and inhibition of FKHR and related FOXO forkhead transcription factors and that androgens provide an AKT-independent cell survival signal in prostate cancer cells. Here, we report receptor-dependent repression of FKHR function by androgens in prostate cancer cells. Transcriptional analysis demonstrated that activation...

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Source

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Identifiers

PMID: 12482965
DOI: 10.1128/MCB.23.1.104-118.2003
PMCID: PMC140652

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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