Migraine: gene mutations and functional consequences.

Abstract excerpt

PURPOSE OF REVIEW: Genetic and functional studies of mutations in familial hemiplegic migraine reveal a major role for disturbed ion transport. Gene identification in common, multifactorial migraine remains challenging. RECENT FINDINGS: Several new mutations have been identified in FHM1, FHM2 and FHM3 genes. Functional consequences of familial hemiplegic migraine mutations point to an important role for cortical...

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