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Inhibition of histone deacetylases in cancer therapy: lessons from leukaemia

23 Feb 2016

Abstract excerpt

Histone deacetylases (HDACs) are a key component of the epigenetic machinery regulating gene expression, and behave as oncogenes in several cancer types, spurring the development of HDAC inhibitors (HDACi) as anticancer drugs. This review discusses new results regarding the role of HDACs in cancer and the effect of HDACi on tumour cells, focusing on haematological malignancies, particularly acute myeloid...

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PMID: 26908329
DOI: 10.1038/bjc.2016.36

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