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Epigenetic Modifiers in Myeloid Malignancies: The Role of Histone Deacetylase Inhibitors

9 Oct 2018

Abstract excerpt

Myeloid hematological malignancies are clonal bone marrow neoplasms, comprising of acute myeloid leukemia (AML), the myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML), the myeloproliferative neoplasms (MPN) and systemic mastocytosis (SM). The field of epigenetic regulation of normal and malignant hematopoiesis is rapidly growing. In recent years, heterozygous somatic mutations in genes...

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PMID: 30304859
DOI: 10.3390/ijms19103091

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