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Genetic determinants of virulence in pathogenic lineage 2 West Nile virus strains.

Emerging infectious diseases - 1 Feb 2008

Botha Elizabeth M, Markotter Wanda, Wolfaardt Mariaan, Paweska Janusz T, Swanepoel Robert, Palacios Gustavio, Nel Louis H, Venter Marietjie

Abstract excerpt

We determined complete genome sequences of lineage 2 West Nile virus (WNV) strains isolated from patients in South Africa who had mild or severe WNV infections. These strains had previously been shown to produce either highly or less neuroinvasive infection and induced genes similar to corresponding highly or less neuroinvasive lineage 1 strains in mice. Phylogenetic and amino acid comparison of highly and less...

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Identifiers

PMID: 18258114
DOI: 10.3201/eid1402.070457
PMCID: PMC2600181

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