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Article

Exposure of hydrophobic core in human prion protein pathogenic mutant H187R.

Journal of biomolecular structure & dynamics - 1 Dec 2010

Zhong Linghao

Abstract excerpt

Pathogenesis studies have revealed that H187R mutation of human prion protein (huPrP) is related to GSS type of TSE diseases. Its pathogenic mechanism is still unclear. We here studied the globular domain of this mutant protein by molecular dynamics simulations. Compared to the wide-type protein, the mutant has similar dynamics and stability profiles in our simulation. Conformational rearrangements are...

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Source

Identifiers

PMID: 20919751
DOI: 10.1080/07391102.2010.10507365

Genes

GSS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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