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GATA3 inhibits GCM1 activity and trophoblast cell invasion

22 Feb 2016

Abstract excerpt

Development of human placenta involves the invasion of trophoblast cells from anchoring villi into the maternal decidua. Placental transcription factor GCM1 regulates trophoblast cell invasion via transcriptional activation of HtrA4 gene, which encodes a serine protease enzyme. The GATA3 transcription factor regulates trophoblast cell differentiation and is highly expressed in invasive murine trophoblast giant...

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PMID: 26899996
DOI: 10.1038/srep21630

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