Phenotypic and molecular analysis of the effect of 20-hydroxyecdysone on the human filarial parasite Brugia malayi.

doi:10.1016/j.ijpara.2016.01.005

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Article

Phenotypic and molecular analysis of the effect of 20-hydroxyecdysone on the human filarial parasite Brugia malayi.

International journal for parasitology - 1 May 2016

Mhashilkar Amruta S, Adapa Swamy R, Jiang Rays H Y, Williams Steven A, Zaky Weam, Slatko Barton E, Luck Ashley N, Moorhead Andrew R, Unnasch Thomas R

Abstract excerpt

A homologue of the ecdysone receptor has been identified and shown to be responsive to 20-hydroxyecdysone in Brugia malayi. However, the role of this master regulator of insect development has not been delineated in filarial nematodes. Gravid adult female B. malayi cultured in the presence of 20-hydroxyecdysone produced significantly more microfilariae and abortive immature progeny than control worms, implicating...

Topics

Animals
Brugia malayi
Ecdysterone
Female
Fertility
Gene Expression Profiling
Helminth Proteins
Humans
Phenotype
Proteomics
RNA, Helminth
Receptors, Steroid
Reverse Transcriptase Polymerase Chain Reaction

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Identifiers

PMID: 26896576
DOI: 10.1016/j.ijpara.2016.01.005
PMCID: PMC4936774

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