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Raising gestational choline intake alters gene expression in DMBA‐evoked mammary tumors and prolongs survival

1 Dec 2008

Abstract excerpt

Choline is an essential nutrient that serves as a donor of metabolic methyl groups used during gestation to establish the epigenetic DNA methylation patterns that modulate tissue-specific gene expression. Because the mammary gland begins its development prenatally, we hypothesized that choline availability in utero may affect the gland's susceptibility to cancer. During gestational days 11-17, pregnant rats were...

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PMID: 19047067
DOI: 10.1096/fj.08-122168

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