Genomic variants in the ASS1 gene, involved in the nitric oxide biosynthesis and signaling pathway, predict hydroxyurea treatment efficacy in compound sickle cell disease/β-thalassemia patients.

doi:10.2217/pgs.16.1

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Genomic variants in the ASS1 gene, involved in the nitric oxide biosynthesis and signaling pathway, predict hydroxyurea treatment efficacy in compound sickle cell disease/β-thalassemia patients.

Pharmacogenomics - 1 Mar 2016

Chalikiopoulou Constantina, Tavianatou Anastasia-Gerasimoula, Sgourou Argyro, Kourakli Alexandra, Kelepouri Dimitra, Chrysanthakopoulou Maria, Kanelaki Vasiliki-Kaliopi, Mourdoukoutas Evangelos, Siamoglou Stavroula, John Anne, Symeonidis Argyris, Ali Bassam R, Katsila Theodora, Papachatzopoulou Adamantia, Patrinos George P

Abstract excerpt

AIM: Hemoglobinopathies exhibit a remarkable phenotypic diversity that restricts any safe association between molecular pathology and clinical outcomes. PATIENTS & METHODS: Herein, we explored the role of genes involved in the nitric oxide biosynthesis and signaling pathway, implicated in the increase of fetal hemoglobin levels and response to hydroxyurea treatment, in 119 Hellenic patients with β-type...

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PMID: 26895070
DOI: 10.2217/pgs.16.1

Genes

ASS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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