Photoactivated hypericin is not genotoxic.

doi:10.4149/gpb_2015045

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Article

Photoactivated hypericin is not genotoxic.

General physiology and biophysics - 1 Apr 2016

Feruszová Jana, Imreová Petronela, Bodnárová Kristína, Ševčovičová Andrea, Kyzek Stanislav, Chalupa Ivan, Gálová Eliška, Miadoková Eva

Abstract excerpt

The study was designed to test the potential photogenotoxicity of hypericin (HYP) at three different levels: primary DNA damages, gene mutations and chromosome aberrations. Primary genetic changes were detected using the comet assay. The potential mutagenic activity of HYP was assessed using the Ames/Salmonella typhimurium assay. Finally, the ability of photoactivated HYP to induce chromosome aberrations was...

Topics

Anthracenes
Cells, Cultured
Chromosome Aberrations
DNA Damage
Dose-Response Relationship, Radiation
Humans
Lymphocytes
Mutagenicity Tests
Mutation
Perylene
Photosensitizing Agents
Radiation Dosage

Source

Open in PubMed

Identifiers

PMID: 26891274
DOI: 10.4149/gpb_2015045

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