Article
Photoactivated hypericin is not genotoxic.
General physiology and biophysics - 1 Apr 2016
Feruszová Jana, Imreová Petronela, Bodnárová Kristína, Ševčovičová Andrea, Kyzek Stanislav, Chalupa Ivan, Gálová Eliška, Miadoková Eva
Abstract excerpt
The study was designed to test the potential photogenotoxicity of hypericin (HYP) at three different levels: primary DNA damages, gene mutations and chromosome aberrations. Primary genetic changes were detected using the comet assay. The potential mutagenic activity of HYP was assessed using the Ames/Salmonella typhimurium assay. Finally, the ability of photoactivated HYP to induce chromosome aberrations was...
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