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Article

T-cell epitope conservation across allergen species is a major determinant of immunogenicity

14 Feb 2016

Abstract excerpt

BACKGROUND: Patients with pollen allergies are frequently polysensitized. Pollens contain epitopes that are conserved across multiple species. OBJECTIVE: We sought to demonstrate that cross-reactive T cells that recognize conserved epitopes show higher levels of expansion than T cells recognizing monospecific epitopes because of more frequent stimulation. METHOD: RNA was sequenced from 9 pollens, and the reads...

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PMID: 26883464
DOI: 10.1016/j.jaci.2015.11.034

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