Article
Grass-specific CD4(+) T-cells exhibit varying degrees of cross-reactivity, implications for allergen-specific immunotherapy.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Jul 2014
Archila L D, DeLong J H, Wambre E, James E A, Robinson D M, Kwok W W
Abstract excerpt
BACKGROUND: Conceptually, allergic responses may involve cross-reactivity by antibodies or T-cells. While IgE cross-reactivity among grass-pollen allergens has been observed, cross-reactivity at the allergen-specific T-cell level has been less documented. Identification of the patterns of cross-reactivity may improve our understanding, allowing optimization of better immunotherapy strategies. OBJECTIVES: We use...
Topics
- Alleles
- Allergens
- Amino Acid Sequence
- Antigens, Plant
- Basophils
- CD4-Positive T-Lymphocytes
- Cross Reactions
- Cytokines
- Desensitization, Immunologic
- Epitopes, T-Lymphocyte
- HLA Antigens
- Humans
- Immunoglobulin E