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Genome‐Wide Mapping of DNA Hydroxymethylation in Osteoarthritic Chondrocytes

1 May 2015

Abstract excerpt

OBJECTIVE: To examine the genome-wide distribution of hydroxymethylated cytosine (5hmC) in osteoarthritic (OA) and normal chondrocytes in order to investigate the effect on OA-specific gene expression. METHODS: Cartilage was obtained from OA patients undergoing total knee arthroplasty or from control patients undergoing anterior cruciate ligament reconstruction. Genome-wide sequencing of 5hmC-enriched DNA was...

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PMID: 25940674
DOI: 10.1002/art.39179

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