Article
Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes.
The Journal of cell biology - 15 Feb 2016
Hecht Vivian C, Sullivan Lucas B, Kimmerling Robert J, Kim Dong-Hwee, Hosios Aaron M, Stockslager Max A, Stevens Mark M, Kang Joon Ho, Wirtz Denis, Vander Heiden Matthew G, Manalis Scott R
Abstract excerpt
Cytokine regulation of lymphocyte growth and proliferation is essential for matching nutrient consumption with cell state. Here, we examine how cellular biophysical changes that occur immediately after growth factor depletion promote adaptation to reduced nutrient uptake. After growth factor withdrawal, nutrient uptake decreases, leading to apoptosis. Bcl-xL expression prevents cell death, with autophagy...
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