Article
The two-component sensor kinase TcsC and its role in stress resistance of the human-pathogenic mold Aspergillus fumigatus.
PloS one - 1 Jan 2012
McCormick Allison, Jacobsen Ilse D, Broniszewska Marzena, Beck Julia, Heesemann Jürgen, Ebel Frank
Abstract excerpt
Two-component signaling systems are widespread in bacteria, but also found in fungi. In this study, we have characterized TcsC, the only Group III two-component sensor kinase of Aspergillus fumigatus. TcsC is required for growth under hyperosmotic stress, but dispensable for normal growth, sporulation and conidial viability. A characteristic feature of the ΔtcsC mutant is its resistance to certain fungicides,...
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