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Article

Gene-Nutrient Interaction between Folate and Dihydrofolate Reductase in Risk for Adenomatous Polyp Occurrence: A Preliminary Report.

Journal of nutritional science and vitaminology - 1 Jan 2015

Choi Jeong-hwa, Yates Zoe, Martin Charlotte, Boyd Lyndell, Ng Xiaowei, Skinner Virginia, Wai Ron, Veysey Martin, Lucock Mark

Abstract excerpt

Folate and related gene variants are significant risk factors in the aetiology of colorectal cancer. Dihydrofolate reductase (DHFR) is critical in the metabolism of synthetic folic acid (pteroylmonoglutamatamic, PteGlu) to tetrahydrofolate following absorption. Therefore, the 19bp deletion variant of DHFR may lead to the alteration of folate-related colorectal disease susceptibility. This study examined the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26875486
DOI: 10.3177/jnsv.61.455

Genes

DHFR

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