Article
Measurement of Blood Thiamine Metabolites for Alzheimer's Disease Diagnosis.
EBioMedicine - 1 Jan 2016
Pan Xiaoli, Fei Guoqiang, Lu Jingwen, Jin Lirong, Pan Shumei, Chen Zhichun, Wang Changpeng, Sang Shaoming, Liu Huimin, Hu Weihong, Zhang Hua, Wang Hui, Wang Zhiliang, Tan Qiong, Qin Yan, Zhang Qunying, Xie Xueping, Ji Yong, Cui Donghong, Gu Xiaohua, Xu Jun, Yu Yuguo, Zhong Chunjiu
Abstract excerpt
BACKGROUND: Brain glucose hypometabolism is an invariant feature and has significant diagnostic value for Alzheimer's disease. Thiamine diphosphate (TDP) is a critical coenzyme for glucose metabolism and significantly reduced in brain and blood samples of patients with Alzheimer's disease (AD). AIMS: To explore the diagnostic value of the measurement of blood thiamine metabolites for AD. METHODS: Blood TDP,...
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