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Small Molecule Inhibitors of BAF; A Promising Family of Compounds in HIV-1 Latency Reversal

27 Nov 2015

Abstract excerpt

Persistence of latently infected cells in presence of Anti-Retroviral Therapy presents the main obstacle to HIV-1 eradication. Much effort is thus placed on identification of compounds capable of HIV-1 latency reversal in order to render infected cells susceptible to viral cytopathic effects and immune clearance. We identified the BAF chromatin remodeling complex as a key player required for maintenance of HIV-1...

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PMID: 26870822
DOI: 10.1016/j.ebiom.2015.11.047

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