Article
n-3 PUFAs enhance the frequency of murine B-cell subsets and restore the impairment of antibody production to a T-independent antigen in obesity.
Journal of lipid research - 1 Nov 2013
Teague Heather, Fhaner Cassie J, Harris Mitchel, Duriancik David M, Reid Gavin E, Shaikh Saame Raza
Abstract excerpt
The role of n-3 polyunsaturated fatty acids (PUFA) on in vivo B-cell immunity is unknown. We first investigated how n-3 PUFAs impacted in vivo B-cell phenotypes and antibody production in the absence and presence of antigen compared with a control diet. Lean mice consuming n-3 PUFAs for 4 weeks displayed increased percentage and frequency of splenic transitional 1 B cells. Upon stimulation with...
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