Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spleen supports a pool of innate-like B cells in white adipose tissue that protects against obesity-associated insulin resistance.

Proceedings of the National Academy of Sciences of the United States of America - 28 Oct 2014

Wu Lan, Parekh Vrajesh V, Hsiao Joseph, Kitamura Daisuke, Van Kaer Luc

Abstract excerpt

Lipid accumulation in obesity triggers a low-grade inflammation that results from an imbalance between pro- and anti-inflammatory components of the immune system and acts as the major underlying mechanism for the development of obesity-associated diseases, notably insulin resistance and type 2 diabetes. Innate-like B cells are a subgroup of B cells that respond to innate signals and modulate inflammatory...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue, White
Share to CD5 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diet, High-Fat

Share to Interleukin-10

Share to Lymphocyte Count

Share to Peritoneal Cavity

Share to Spleen

Share to Splenectomy

Source

Open in PubMed Open full text

Identifiers

PMID: 25313053
DOI: 10.1073/pnas.1324052111
PMCID: PMC4217427

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spleen supports a pool of innate-like B cells in white adipose tissue that protects against obesity-associated insulin resistance.PMID 25313053Read ↗

B Lymphocytes and Adipose Tissue Inflammation.Semantic proximity Read ↗

The effects of diet-induced obesity on B cell function.Semantic proximity Read ↗

The Immune Landscape of Visceral Adipose Tissue During Obesity and AgingSemantic proximity Read ↗

Biology and function of adipose tissue macrophages, dendritic cells and B cells.Semantic proximity Read ↗

Deciphering visceral adipose tissue regulatory T cells: Key contributors to metabolic healthSemantic proximity Read ↗

Visceral adipose tissue Tregs and the cells that nurture themSemantic proximity Read ↗

B Cells with a Senescent-Associated Secretory Phenotype Accumulate in the Adipose Tissue of Individuals with ObesitySemantic proximity Read ↗

MicroRNA-regulated B cells in obesitySemantic proximity Read ↗

Phenotypic and functional features of B cells from two different human subcutaneous adipose depots.Semantic proximity Read ↗

Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance.Semantic proximity Read ↗

High-Fat Diet Rapidly Modifies Trafficking, Phenotype, and Function of Plasmacytoid Dendritic Cells in Adipose Tissue.Semantic proximity Read ↗

Six Tissue Transcriptomics Reveals Specific Immune Suppression in Spleen by Dietary Polyunsaturated Fatty Acids.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.