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Article

Low Dose Iron Treatments Induce a DNA Damage Response in Human Endothelial Cells within Minutes.

PloS one - 1 Jan 2016

Mollet Inês G, Patel Dilipkumar, Govani Fatima S, Giess Adam, Paschalaki Koralia, Periyasamy Manikandan, Lidington Elaine C, Mason Justin C, Jones Michael D, Game Laurence, Ali Simak, Shovlin Claire L

Abstract excerpt

BACKGROUND: Spontaneous reports from patients able to report vascular sequelae in real time, and recognition that serum non transferrin bound iron may reach or exceed 10μmol/L in the blood stream after iron tablets or infusions, led us to hypothesize that conventional iron treatments may provoke acute vascular injury. This prompted us to examine whether a phenotype could be observed in normal human endothelial...

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PMID: 26866805
DOI: 10.1371/journal.pone.0147990
PMCID: PMC4750942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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