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Article

MicroRNA-Detargeted Mengovirus for Oncolytic Virotherapy

11 Feb 2016

Abstract excerpt

UNLABELLED: Mengovirus, a member of thePicornaviridaefamily, has a broad cell tropism and can cause encephalitis and myocarditis in multiple mammalian species. Attenuation has been achieved by shortening the polycytidine tract in the 5' noncoding region (NCR). A poly(C)-truncated strain of mengovirus, vMC24, resulted in significant tumor regression in immunocompetent BALB/c mice bearing syngeneic MPC-11...

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PMID: 26865716
DOI: 10.1128/jvi.02810-15

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