Article
[Advance of molecular subtyping and precise treatment for gliomas].
Zhonghua wai ke za zhi [Chinese journal of surgery] - 1 Jan 2017
Hua W, Mao Y
Abstract excerpt
With the advance of genomics research, there have been a new breakthrough in the molecular classification of gliomas. Glioblastoma (WHO grade Ⅳ) could be subtyped to proneural, neural, classical, and mesochymal according to the mRNA expression. Lower grade gliomas (WHO grade Ⅱ and Ⅲ) could be divided into 5 types using 1p/19q co-deletion, isocitrate dehydrogenase(IDH) mutation, and TERTp (promotor region)...
Topics
- Brain Neoplasms
- Chromosome Deletion
- Chromosomes, Human, Pair 1
- Genomics
- Glioblastoma
- Glioma
- Humans
- Isocitrate Dehydrogenase
- Mutation
- Precision Medicine
- Prognosis
