Article
Association of Novel Nonsynonymous Single Nucleotide Polymorphisms in ampD with Cephalosporin Resistance and Phylogenetic Variations in ampC, ampR, ompF, and ompC in Enterobacter cloacae Isolates That Are Highly Resistant to Carbapenems.
Antimicrobial agents and chemotherapy - 1 Apr 2016
Babouee Flury Baharak, Ellington Matthew J, Hopkins Katie L, Turton Jane F, Doumith Michel, Loy Richard, Staves Peter, Hinic Vladimira, Frei Reno, Woodford Neil
Abstract excerpt
InEnterobacter cloacae, the genetic lesions associated with derepression of the AmpC β-lactamase include diverse single nucleotide polymorphisms (SNPs) and/or indels in theampDandampRgenes and SNPs inampC, while diverse SNPs in the promoter region or SNPs/indels within the coding sequence of outer membrane proteins have been described to alter porin production leading to carbapenem resistance. We sought to define...
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