Article
A Common Polymorphism in a Williams Syndrome Gene Predicts Amygdala Reactivity and Extraversion in Healthy Adults.
Biological psychiatry - 1 Feb 2017
Swartz Johnna R, Waller Rebecca, Bogdan Ryan, Knodt Annchen R, Sabhlok Aditi, Hyde Luke W, Hariri Ahmad R
Abstract excerpt
BACKGROUND: Williams syndrome (WS), a genetic disorder resulting from hemizygous microdeletion of chromosome 7q11.23, has emerged as a model for identifying the genetic architecture of socioemotional behavior. Common polymorphisms in GTF2I, which is found within the WS microdeletion, have been associated with reduced social anxiety in the general population. Identifying neural phenotypes affected by these...
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