Article
Mup-knockout mice generated through CRISPR/Cas9-mediated deletion for use in urinary protein analysis.
Acta biochimica et biophysica Sinica - 1 May 2016
Yang Haixia, Zhang Wei, Lu Shan, Lu Guangqing, Zhang Hongjuan, Zhuang Yinghua, Wang Yue, Dong Mengqiu, Zhang Yu, Zhou Xingang, Wang Peng, Yu Lei, Wang Fengchao, Chen Liang
Abstract excerpt
Major urinary proteins (MUPs) are the most abundant protein species in mouse urine, accounting for more than 90% of total protein content. Twenty-one Mup genes and 21 pseudogenes are clustered in a region of around 2 megabase pairs (Mbp) on chromosome 4. A Mup-knockout mouse model would greatly facilitate researches in the field of proteomic analysis of mouse urine. Here, we report the successful knockout of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.