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Article

Major urinary protein (Mup) gene family deletion drives sex-specific alterations in the house-mouse gut microbiota.

Microbiology spectrum - 6 Feb 2024

Real Madalena V F, Colvin Melanie S, Sheehan Michael J, Moeller Andrew H

Abstract excerpt

The gut microbiota is shaped by host metabolism. In house mice (Mus musculus), major urinary protein (MUP) pheromone production represents a considerable energy investment, particularly in sexually mature males. Deletion of the Mup gene family shifts mouse metabolism toward an anabolic state, marked by lipogenesis, lipid accumulation, and body mass increases. Given the metabolic implications of MUPs, they may...

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Identifiers

PMID: 38170981
DOI: 10.1128/spectrum.03566-23
PMCID: PMC10846032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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