Article
Somatic Mosaic Mutations in PPM1D and TP53 in the Blood of Women With Ovarian Carcinoma.
JAMA oncology - 1 Mar 2016
Swisher Elizabeth M, Harrell Maria I, Norquist Barbara M, Walsh Tom, Brady Mark, Lee Ming, Hershberg Robert, Kalli Kimberly R, Lankes Heather, Konnick Eric Q, Pritchard Colin C, Monk Bradley J, Chan John K, Burger Robert, Kaufmann Scott H, Birrer Michael J
Abstract excerpt
IMPORTANCE: Somatic mosaic mutations in PPM1D have been reported in patients with breast cancer, lung cancer, and ovarian cancer (OC), but cause or effect has not been established. OBSERVATIONS: To test the hypothesis that somatic mosaic mutations are associated with chemotherapy exposure, we used massively parallel sequencing to quantitate mutations in peripheral blood mononuclear cells (PBMCs) of 686 women with...
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