Article
Screening for Pancreatic Adenocarcinoma in BRCA2 Mutation Carriers: Results of a Disease Simulation Model.
EBioMedicine - 1 Dec 2015
Pandharipande Pari V, Jeon Alvin, Heberle Curtis R, Dowling Emily C, Kong Chung Yin, Chung Daniel C, Brugge William R, Hur Chin
Abstract excerpt
BACKGROUND: BRCA2 mutation carriers are at increased risk for multiple cancers including pancreatic adenocarcinoma (PAC). Our goal was to compare the effectiveness of different PAC screening strategies in BRCA2 mutation carriers, from the standpoint of life expectancy. METHODS: A previously published Markov model of PAC was updated and extended to incorporate key aspects of BRCA2 mutation carrier status,...
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