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Understanding of the drug resistance mechanism of hepatitis C virus NS3/4A to paritaprevir due to D168N/Y mutations: A molecular dynamics simulation perspective.

Computational biology and chemistry - 1 Dec 2019

Boonma Thitiya, Nutho Bodee, Rungrotmongkol Thanyada, Nunthaboot Nadtanet

Abstract excerpt

Hepatitis C virus (HCV) NS3/4A protease is an attractive target for the development of antiviral therapy. However, the evolution of antiviral drug resistance is a major problem for treatment of HCV infected patients. Understanding of drug-resistance mechanisms at molecular level is therefore very important for the guidance of further design of antiviral drugs with high efficiency and specificity. Paritaprevir is...

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PMID: 31751885
DOI: 10.1016/j.compbiolchem.2019.107154

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