Article
Mutations acquired during cell culture isolation may affect antigenic characterisation of influenza A(H3N2) clade 3C.2a viruses.
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin - 1 Jan 2016
Skowronski Danuta M, Sabaiduc Suzana, Chambers Catharine, Eshaghi Alireza, Gubbay Jonathan B, Krajden Mel, Drews Steven J, Martineau Christine, De Serres Gaston, Dickinson James A, Winter Anne-Luise, Bastien Nathalie, Li Yan
Abstract excerpt
As elsewhere, few (< 15%) sentinel influenza A(H3N2) clade 3C.2a viruses that dominated in Canada during the 2014/15 season could be antigenically characterised by haemagglutination inhibition (HI) assay. Clade 3C.2a viruses that could be HI-characterised had acquired genetic mutations during in vitro cell culture isolation that modified the potential glycosylation motif found in original patient specimens and...
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