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Article

Amino Acid Substitutions Account for Most MexS Alterations in Clinical nfxC Mutants of Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy - 1 Apr 2016

Richardot Charlotte, Juarez Paulo, Jeannot Katy, Patry Isabelle, Plésiat Patrick, Llanes Catherine

Abstract excerpt

Multidrug-resistant mutants ofPseudomonas aeruginosathat overproduce the active efflux system MexEF-OprN (callednfxCmutants) have rarely been characterized in the hospital setting. Screening of 221 clinical strains exhibiting a reduced susceptibility to ciprofloxacin (a substrate of MexEF-OprN) and imipenem (a substrate of the negatively coregulated porin OprD) led to the identification of 43 (19.5%)nfxCmutants....

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Identifiers

PMID: 26833155
DOI: 10.1128/AAC.02622-15
PMCID: PMC4808181

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Source receipt: pubmed, retrieved 7 Sept 2026.

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