Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Testotoxicosis: Report of Two Cases, One with a Novel Mutation in LHCGR Gene.

Journal of clinical research in pediatric endocrinology - 1 Sept 2015

Özcabı Bahar, Tahmiscioğlu Bucak Feride, Ceylaner Serdar, Özcan Rahşan, Büyükünal Cenk, Ercan Oya, Tüysüz Beyhan, Evliyaoğlu Olcay

Abstract excerpt

Testotoxicosis is a rare disorder which presents as isosexual peripheral precocious puberty in males. Despite the pattern of autosomal dominant inheritance, sporadic cases also may occur. Due to activating mutation in luteinizing hormone (LH))/choriogonadotropin receptor (LHCGR) gene, early virilization and advancement in bone age are common with increased serum testosterone levels above adult ranges, despite low...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Androgen Antagonists
Share to Anilides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aromatase Inhibitors

Share to Cytochrome P-450 CYP3A Inhibitors

Share to Nitriles

Share to Puberty, Precocious

Share to Receptors, LH

Share to Triazoles

Source

Open in PubMed Open full text

Identifiers

PMID: 26831561
DOI: 10.4274/jcrpe.2067
PMCID: PMC4677562

Genes

LHCGR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Testotoxicosis: Report of Two Cases, One with a Novel Mutation in LHCGR Gene.PMID 26831561Read ↗

A Case of Familial Male-limited Precocious Puberty with a Novel MutationSemantic proximity Read ↗

Spontaneous fertility in a male patient with testotoxicosis despite suppression of FSH levels.Semantic proximity Read ↗

Novel C617Y mutation in the 7th transmembrane segment of luteinizing hormone/choriogonadotropin receptor in a Japanese boy with peripheral precocious pubertySemantic proximity Read ↗

Effectiveness of anastrozole and cyproterone acetate in two brothers with familial male precocious puberty.Semantic proximity Read ↗

Variable presentation of precocious puberty associated with the D564G mutation of the LHCGR gene in children with testotoxicosis.Semantic proximity Read ↗

Update on the etiology, diagnosis and therapeutic management of sexual precocity.Semantic proximity Read ↗

Cosegregation of a novel mutation in the sixth transmembrane segment of the luteinizing/choriogonadotropin hormone receptor with two Brazilian siblings with severe testotoxicosis.Semantic proximity Read ↗

Gonadotropin independent sexual precocity in a Pakistani male infant from an activating mutation in LHCGR gene.Semantic proximity Read ↗

Severe testotoxicosis phenotype associated with Asp578-->Tyr mutation of the lutrophin/choriogonadotrophin receptor gene.Semantic proximity Read ↗

Testotoxicosis. An unusual presentation and novel gene mutation.Semantic proximity Read ↗

Reply; Testotoxicosis: Report of Two Cases, One with a Novel Mutation in LHCGR Gene.Semantic proximity Read ↗

Mutational analysis of the luteinizing hormone receptor gene in two individuals with Leydig cell tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.