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Article

Effect of 3'UTR RET Variants on RET mRNA Secondary Structure and Disease Presentation in Medullary Thyroid Carcinoma.

PloS one - 1 Jan 2016

Ceolin Lucieli, Romitti Mirian, Siqueira Débora Rodrigues, Vaz Ferreira Carla, Oliboni Scapineli Jessica, Assis-Brazil Beatriz, Vieira Maximiano Rodolfo, Dias Amarante Tauanne, de Souza Nunes Miriam Celi, Weber Gerald, Maia Ana Luiza

Abstract excerpt

BACKGROUND: The RET S836S variant has been associated with early onset and increased risk for metastatic disease in medullary thyroid carcinoma (MTC). However, the mechanism by which this variant modulates MTC pathogenesis is still open to discuss. Of interest, strong linkage disequilibrium (LD) between RET S836S and 3'UTR variants has been reported in Hirschsprung's disease patients. OBJECTIVE: To evaluate the...

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Identifiers

PMID: 26829565
DOI: 10.1371/journal.pone.0147840
PMCID: PMC4734678

Genes

RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effect of 3'UTR RET Variants on RET mRNA Secondary Structure and Disease Presentation in Medullary Thyroid Carcinoma.PMID 26829565Read ↗

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