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Article

Histomolecular profiling of pleomorphic, spindle cell, and giant cell carcinoma of the lung for targeted therapies.

Human pathology - 1 Mar 2016

Forest Fabien, Yvorel Violaine, Karpathiou Georgia, Stachowicz Marie-Laure, Vergnon Jean-Michel, Fournel Pierre, Tiffet Olivier, Trombert Béatrice, Péoc'h Michel

Abstract excerpt

In pleomorphic, spindle cell, and giant cell carcinoma (PSCGC) of the lung, we wondered if an integrated diagnosis including morphological and immunohistochemical features could be related to molecular status. We performed immunohistochemistry on 35 PSCGCs against TTF1, napsin A, p40, ALK, ROS1, and c-MET. Mutational status regarding EGFR, KRAS, BRAF, HER2, and PIK3CA genes was established. Of 18 PSCGCs with...

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Source

Identifiers

PMID: 26826416
DOI: 10.1016/j.humpath.2015.10.006

Genes

ALK
BRAF
EGFR
KRAS
MET
ROS1
TTF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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