Virulence profile of carbapenem-resistant Klebsiella pneumoniae strains by an in vivo model of Galleria mellonella.

doi:10.1128/spectrum.02215-24

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Article

Virulence profile of carbapenem-resistant Klebsiella pneumoniae strains by an in vivo model of Galleria mellonella.

Microbiology spectrum - 4 Feb 2025

Guembe María, Hafian Rama, Díaz-Navarro Marta, Visedo Andrés, De Maio Flavio, Pimpinelli Fulvia, Cavallo Ilaria, Truglio Mauro, Sivori Francesca, Di Domenico Enea Gino

Abstract excerpt

Klebsiella pneumoniae is a significant healthcare-associated pathogen, notable for its diverse virulence and antibiotic resistance profiles. This study aimed to characterize the genotypic and phenotypic diversity of K. pneumoniae isolates and evaluate their virulence using the Galleria mellonella model. Biomass production, metabolic activity, capsule formation, and siderophore production were assessed in 27 K....

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Topics

Klebsiella pneumoniae
Animals
Virulence
Klebsiella Infections
Carbapenems
Moths

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Anti-Bacterial Agents

Disease Models, Animal

Bacterial Proteins

Humans

beta-Lactamases

Carbapenem-Resistant Enterobacteriaceae

Microbial Sensitivity Tests

Genotype

Virulence Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 39804075
DOI: 10.1128/spectrum.02215-24
PMCID: PMC11792541

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