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Article

GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis.

Scientific reports - 28 Jan 2016

Abbey Megha, Hakim Cosima, Anand Roopsee, Lafera Juri, Schambach Axel, Kispert Andreas, Taft Manuel H, Kaever Volkhard, Kotlyarov Alexey, Gaestel Matthias, Menon Manoj B

Abstract excerpt

Septin 7 (SEPT7) has been described to be essential for successful completion of cytokinesis in mouse fibroblasts, and Sept7-deficiency in fibroblasts constitutively results in multinucleated cells which stop proliferation. Using Sept7(flox/flox)fibroblasts we generated a cellular system, where the cytokinetic defects of Cre-mediated deletion of the Sept7 gene can be rescued by ectopically expressed...

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Identifiers

PMID: 26818767
DOI: 10.1038/srep20007
PMCID: PMC4730212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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